How TRIP13 inactivates the spindle Assembly checkpoint

Congratulations to Qiaozhen and the rest of the lab on the recent publication of our work on Pch2/TRIP13, a AAA+ ATPase that functions in both meiotic recombination control and in the spindle assembly checkpoint. The key result of this paper is that TRIP13, with the help of the adapter protein p31(comet), can actually convert the MAD2 protein from its signaling-active "closed" state to its inactive "open" state. We propose that this conformational conversion underlies TRIP13-mediated spindle assembly checkpoint inactivation. In the future, we will be working on how Pch2/TRIP13 might use a similar activity to regulate the conserved HORMAD proteins in meiosis (see our earlier work in Developmental Cell on these proteins), and we hope to also identify any additional substrates for TRIP13. You can read all about it at eLife:

TRIP13 is a protein-remodeling AAA+ ATPase that catalyzes MAD2 conformation switching

P.S. I must say that submitting to eLife was a pleasure. The reviews were among the most measured, helpful, and constructive I've ever experienced. Highly recommended, especially to fellow junior faculty!